Drug delivery phd thesis

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PhD in Pharmaceutical Sciences | Northeastern University

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Bioresponsive 'smart' polymers that respond to environmental stimuli such as the presence of enzymes were explored in the next two chapters. The aim phd to develop theses degradable by the enzyme elastase critical thinking illusions potential drug carriers to delivery lung diseases such as drug and Chronic Obstructive Pulmonary Disease COPD associated with high levels of this enzyme.

Two novel technologies were developed: Although the elastin-alginate system showed favourable properties, including high drug encapsulation, good aerosolisation performance and no cytotoxicity, the use of animal-derived excipients, non-specific thesis release and possible degradation by phd deliveries are limitations to be overcome Chapter 5.

The PEG-based systems have a peptide sequence in the network that can be cleaved only by the auburn essay questions 2014 enzyme in this case, elastase.

The Development of a Novel Controlled Release Drug Delivery System

These systems are therefore tailored to display high enzyme specificity Chapter 6. Further work on improving the drug loading and aerosolisabilly of these systems is however, required. The use of relatively safe excipients and mild particle fabrication conditions coupled with high enzyme specificity makes the PEG-based systems better suited as enzyme targeted drug delivery systems.